Platelet-Rich Plasma (PRP)
Scott Vizzi, M.D. | Shoulder Surgeon Serving St. Petersburg, Sarasota, Palm Harbor, and Largo, Florida
PRP Therapy
Platelet-rich plasma (PRP) therapy is a biologic treatment that uses concentrated platelets derived from your own blood in an effort to support healing.
Platelets contain growth factors and signaling proteins involved in tissue repair and inflammation regulation. The concept behind PRP therapy is that concentrating and delivering these biologic components directly to an area of injury may help stimulate a healing response.
How PRP Is Prepared
PRP is created using your own blood during an in-office visit.
- Blood Draw: A small amount of blood is drawn from your arm, similar to routine lab testing.
- Centrifugation: The blood is placed in a centrifuge, which spins at high speed to separate its components.
- Platelet Concentration: The platelet-rich layer is isolated, producing a solution with a higher concentration of platelets than baseline blood levels.
- Injection: The PRP is injected into the targeted area, sometimes under ultrasound guidance to support accuracy.
The entire process typically takes less than an hour.
Conditions That May Be Considered for PRP Therapy
PRP injections may be discussed in selected patients with:
- Rotator cuff tendinopathy
- Partial-thickness rotator cuff tears
- Subacromial bursitis
- Mild to moderate glenohumeral arthritis
- Biceps tendinitis
- Partial labral injury without instability
What to Expect After Injection
The injection site may be sore for several days following treatment. Temporary inflammation is expected as part of the intended biologic response. Patients are often advised to avoid anti-inflammatory medications for a short period, as these may interfere with the inflammatory phase associated with PRP therapy’s proposed mechanism. Activity modification may be recommended temporarily, followed by gradual return to strengthening or rehabilitation exercises as directed.
Setting Realistic Expectations
Response to PRP injections varies by condition and individual factors. Symptom improvement may develop gradually over several weeks to months. Some patients consider repeat injections depending on response and clinical discussion. In some cases, physical therapy may be recommended alongside PRP therapy.
Is PRP Therapy Right for You?
If you are experiencing persistent pain that has not improved with conservative treatment, and you are exploring alternatives to surgery, PRP therapy may be worth discussing. A consultation allows for careful evaluation of your diagnosis, review of imaging, and an honest discussion about whether PRP therapy aligns with your goals.